The concentrations of nine heavy metals accumulated in different organs of two crab species collected from the South East coast of India were estimated. The order of trace metal concentration in different organs of Portunus pelagicus was Cu > Mn > Cd > Ni > Pb > Co > Hg = Cr = U in gills, Cu > Mn > Cd > Ni > Pb = Co > Hg > Cr = U in hepatopancreas, and Cu > Cr > Ni > Mn > Cd > Pb > Co > Hg > U in muscles, whereas that for Portunus sanguinolentus was Cu > Mn > Cd > Ni > Pb > Co > Hg > Cr = U in gills, Cu > Mn > Cd > Ni > Pb = Co > U > Cr = Hg in hepatopancreas, and Cr > Cu > Ni > Mn > Cd > Co > Pb > Hg = U in muscles. The order of trace metal uptake for different organs was gills > hepatopancreas > muscles. Individual mean bioaccumulation index (IMBI) values varied between 0.0 and 0.52, 0.0 and 0.28, and 0.06 and 0.30 for gills, hepatopancreas, and muscles, respectively. Cr in muscles of P. sanguinolentus and Cu and Cd in all organs of both the species were found to be higher than the maximum permitted concentration recommended by food safety guidelines. Target hazard quotient (THQ) results suggested that there is a potential risk due to Co, Cd, and Cr, particularly for children, if the crab consumption frequency is more than once a month.