Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost power.

Affiliation

Atkinson EG(1)(2)(3), Maihofer AX(4), Kanai M(5)(6)(7)(8)(9), Martin AR(5)(6)(7), Karczewski KJ(5)(6), Santoro ML(6)(10)(11), Ulirsch JC(5)(6)(7)(12), Kamatani Y(13), Okada Y(9)(14)(15), Finucane HK(5)(6)(7), Koenen KC(6)(16), Nievergelt CM(#)(4), Daly MJ(#)(5)(6)(7)(17), Neale BM(#)(5)(6).
Author information:
(1)Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. [Email]
(2)Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. [Email]
(3)Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. [Email]
(4)Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
(5)Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
(6)Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
(7)Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
(8)Program in Bioinformatics and Integrative Genomics, Harvard Medical School, Boston, MA, USA.
(9)Department of Statistical Genetics, Graduate School of Medicine, Osaka University, Suita, Japan.
(10)Departamento de Psiquiatria, Universidade Federal de São Paulo, São Paulo, Brazil.
(11)Departamento de Morfologia e Genética, Universidade Federal de São Paulo, São Paulo, Brazil.
(12)Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA.
(13)Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
(14)Laboratory of Statistical Immunology, Immunology Frontier Research Center
(WPI-IFReC), Osaka University, Suita, Japan.
(15)Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan.
(16)Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
(17)Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
(#)Contributed equally

Abstract

Comment in Nat Genet. 2021 Dec;53(12):1634-1635. Nat Genet. 2021 Dec;53(12):1631-1633.