Translational control mechanisms in cutaneous malignant melanoma: the role of eIF2α.

Affiliation

Dermatology Unit, Department of Surgical, Medical, Dental and Morphological Science with Interest Transplant, Oncological and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy. [Email]

Abstract

Melanoma cells develop adaptive responses in order to cope with particular conditions of tumor microenvironment, characterized by stress conditions and deregulated proliferation. Recently, the interplay between the stress response and the gene expression programs leading to metastatic spread has been reported.

Keywords

BRAF,Metastatic melanoma,MiT family,Nuclear peIF2α,Structural analysis,eIF2α,