Use of a Linear Accelerator for Conducting In Vitro Radiobiology Experiments.


Department of Cancer Biology, Cleveland Clinic; Department of Radiation Oncology, Cleveland Clinic; [Email]


Radiation therapy remains one of the cornerstones of cancer management. For most cancers, it is the most effective, nonsurgical therapy to debulk tumors. Here, we describe a method to irradiate cancer cells with a linear accelerator. The advancement of linear accelerator technology has improved the precision and efficiency of radiation therapy. The biological effects of a wide range of radiation doses and dose rates continue to be an intense area of investigation. Use of linear accelerators can facilitate these studies using clinically relevant doses and dose rates.

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