Variability and uncertainty in the rodent controlled cortical impact model of traumatic brain injury.


Mechanical Engineering and Florida Center for Advanced Aero-Propulsion, FAMU-FSU College of Engineering, Tallahassee, FL, United States. Electronic address: [Email]


Controlled cortical impact (CCI) has emerged as one of the most flexible and clinically applicable approaches for the induction of traumatic brain injury (TBI) in rodents and other species. Although this approach has been shown to model cognitive and functional outcomes associated with TBI in humans, recent work has shown that CCI is limited by excessive variability in lesion size despite attempts to control velocity, impact depth, and dwell time.