Dyslexia, dyscalculia and their comorbid manifestation are prevalent disorders associated with well-documented behavioral manifestations. However, attempts to relate these manifestations to abnormalities in brain structure have yielded mixed results, with no clear consistency across a range of measures. In this study, we used a unique design including adults with dyslexia, dyscalculia, both disorders and controls, to explore differences in gray matter characteristics across groups. Specifically, we examined whether dyslexia, dyscalculia, or their comorbid manifestation could be related to volumetric and surface characteristics of gray matter, using voxel-based and surface-based morphometry. We demonstrate with Bayesian analyses that the present data favor the null model of no differences between groups across the brain, a result that is in line with recent findings in this field of research. Importantly, we provide detailed statistical maps to enable robust assessment of our findings, and to promote cumulative evaluation of the evidence. Together, these findings suggest that gray matter differences associated with dyslexia and dyscalculia might not be as reliable as suggested by previous literature, with important implications for our understanding of these disorders.