Vps4b heterozygous mice do not develop tooth defects that replicate human dentin dysplasia I.


Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, No.1023, Shatai South Road, Guangzhou, 510515, People's Republic of China. [Email]


Vacuolar protein sorting-associated protein 4B (VPS4B) is a member of the ATP enzyme AAA protein family, and is mainly involved in protein degradation and cell membrane fusion. Recently, a dominant mutation in this gene was identified in human dentin dysplasia type I (DD-I). Herein, we report the generation of Vps4b knockout (Vps4b KO) mice; however, the homozygous Vps4b KO mutation was embryonic lethal at the early stages of embryo development, and we therefore report the results of heterozygous mutant mice.


Dentin dysplasia,Phenotype,Vacuolar protein sorting 4B,Vps4b +/− mice,