YY1: A novel therapeutic target for diabetic nephropathy orchestrated renal fibrosis.


Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, China. Electronic address: [Email]


Renal fibrosis promotes the development of diabetic nephropathy (DN). A growing number of studies have reported that Yin Yang 1 (YY1), which is involved in cellular proliferation and differentiation, plays a crucial role in the pathogenesis of many diseases, such as pulmonary fibrosis, hepatic steatosis and cancer.


Diabetic nephropathy,Epithelial-mesenchymal transition,Renal fibrosis,YY1,α-SMA,