Zn-doping of silicate and hydroxyapatite-based cements: Dentin mechanobiology and bioactivity.

Affiliation

Toledano M(1), Osorio R(2), Vallecillo-Rivas M(2), Osorio E(2), Lynch CD(3), Aguilera FS(2), Toledano R(2), Sauro S(4).
Author information:
(1)University of Granada, Faculty of Dentistry, Dental Materials Section, Colegio Máximo de Cartuja S/n, Granada, 18071, Spain. Electronic address: [Email]
(2)University of Granada, Faculty of Dentistry, Dental Materials Section, Colegio Máximo de Cartuja S/n, Granada, 18071, Spain.
(3)University Dental School & Hospital/University College Cork, Wilton, Cork, Ireland.
(4)University of CEU-Cardenal Herrera, Dental Biomaterials and Minimally Invasive Dentistry, Department of Dentistry, Faculty of Sciences and Health, Valencia, Spain; Department of Therapeutic Dentistry, I.M. Sechenov First Moscow State Medical University, 119146, Moscow, Russia.

Abstract

The objective was to state zinc contribution in the effectiveness of novel zinc-doped dentin cements to achieve dentin remineralization, throughout a literature or narrative exploratory review. Literature search was conducted using electronic databases, such as PubMed, MEDLINE, DIMDI, Embase, Scopus and Web of Science. Both zinc-doping silicate and hydroxyapatite-based cements provoked an increase of both bioactivity and intrafibrillar mineralization of dentin. Zinc-doped hydroxyapatite-based cements (oxipatite) also induced an increase in values of dentin nano-hardness, Young's modulus and dentin resistance to deformation. From Raman analyses, it was stated higher intensity of phosphate peaks and crystallinity as markers of dentin calcification, in the presence of zinc. Zinc-based salt formations produced low microleakage and permeability values with hermetically sealed tubules at radicular dentin. Dentin treated with oxipatite attained preferred crystal grain orientation with polycrystalline lattices. Thereby, oxipatite mechanically reinforced dentin structure, by remineralization. Dentin treated with oxipatite produced immature crystallites formations, accounting for high hydroxyapatite solubility, instability and enhanced remineralizing activity.