l-arginine alleviates doxorubicin-induced endothelium-dependent dysfunction by promoting nitric oxide generation and inhibiting apoptosis.


Institute of Cardiovascular Diseases, The First Affiliated Hospital of Dalian Medical University, Dalian, China. Electronic address: [Email]


Patients with doxorubicin (Dox) treatment have a high risk of developing vascular toxicity with an unknown mechanism. l-arginine is a substrate for nitric oxide (NO). The decreased level of arginine-NO metabolite in Dox-treated cancer patients was associated with increased level of vascular damage, which promoted us to investigate the mechanism of Dox-induced vascular dysfunction and verify whether l-arginine supplement could alleviate this vasculotoxic effect.


Apoptosis,Doxorubicin,Reactive oxygen species,Vascular toxicity,l-arginine,

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