Characterization of Membrane of Poly (L,co-D,L-lactic acid-co-trimethylene carbonate) (PLDLA-co-TMC) (50/50) loaded with Silk Fibroin

Daniel Komatsu, Norberto Aranha, Marco Vinicius Chaud*, José Martins de Oliveira Júnior, Daniel Vinícius Mistura, Adriana Motta, Eliana A. R. Duek

Qiqing Zhang(zhangqiq@126.com)

Marzio Sorlini(marzio.sorlini@supsi.ch)

F Guillermo D(fgb@um.es)

Pranab Goswami(pgoswami@iitg.ernet.in)

Marco Vin

Silk produced by Bombyx-mori consists of two proteins sericin and fibroin. Silk Fibroin (SF) an attractive material for epithelial tissue regeneration. The aim of this study was to characterize membranes of PLDLA-co-TMC/SF once it could be used as a wound dressing to burn treatment and epithelial tissue regeneration. Membranes of Poly(L-co-D,L-lactic acid-co-TMC)/SF were prepared by casting and it was analysed by: FTIR - there was no change in the PLDLA-co-TMC spectrum after SF be added in this polymer, Swelling Test – the samples with 5% SF had a different swelling behaviour of PLDLA-co-TMC. Membrane with 5% SF showed swelling rate faster than PLDLA-co-TMC. Contact angle measurement - PLDLA-co-TMC (50/50) showed a contact angle value higher than samples with SF. SEM – the addition of SF in PLDLA-co-TMC apparently leaves the polymer surface more roughened. Tensile test - there was a decrease in the Young\'s modulus and there was an increase in the elongation at break of PLDLA-co-TMC/SF, DSC – SF did not change the glass temperature (Tg) of PLDLA-co-TMC. The membrane of PLDLA-co-TMC/SF was characterized and it has potential to be used as a wound dressing to burn treatment and epithelial tissue regeneration.

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