Journal of Advances In Allergy & Immunologic Diseases
Call Us: +1 6469050407
  editor@siftdesk.org Sign In | Register
  • Home
  • About Us
  • Journals
  • Guidelines
    • Author Guidelines
    • Editor Guidelines
    • Reviewer Guidelines
  • Policies
    • Publication Ethics
    • Peer Review
    • Open Access
    • Terms & Conditions
Logo
  • Journal Home
  • Special Issue Topics
  • Article In Press
  • Current Issue
  • Archive
  • Submit Manuscript
  • Editorial Members
  • Indexing Archive
  • Processing Fee

© 2010 - 2020 Copyright Sift Desk Journals. All Rights Reserved

profile

Journal of Advances In Allergy & Immunologic Diseases

Journal of Advances In Allergy & Immunologic Diseases(JAAID)

ISSN: 2575-6184

Impact Factor: 0.431

Immunological Role of the Maternal Uterine Microbiome in Pregnancy

Submit Manuscript on this topic
Indexed Articles

Description

The success of implantation and pregnancy development is based on interactive processes and complex signaling between embryonic and maternal tissues. Modulation of the maternal immune system prior to conception thus plays a major role in determining subsequent pregnancy outcome. During early pregnancy, even subtle alterations in endometrial immunity and in the surrounding environment can have potentially negative impacts on the implantation process and placental development. Consistent with this, several studies have shown that an abnormal endometrial inflammatory status is associated with recurrent pregnancy loss. Furthermore, reduced immune tolerance to trophoblastic tissues has been suggested as an early mechanism responsible for “poor placentation” and pre-eclampsia, the obstetric syndrome characterized by the occurrence of arterial hypertension and proteinuria, which is still a main cause of maternal and neonatal morbidity and mortality.

Growing evidence suggests that both local and systemic immunity are greatly influenced by the microbiota. Interestingly, recent work suggests that the uterus is likely a non-sterile compartment. Lessons learned from the gut microbiome indicate that the uterine microbiome may be able to modulate immune cell subsets needed for implantation, thereby having potential implications for placental development and pregnancy outcome. The uterine microbiota can also be crucial in protection against uterine infections by defending their niche and competing with pathogens. This may have huge implications for reducing the risk of chorioamniotitis, responsible for 40-70% preterm births due to premature membrane rupture and/or spontaneous labor. However, the impact of maternal bacterial colonization on pregnancy outcomes depends not only on the composition of the microbiome, but also on genetic factors and environmental stimuli, that are able to influence maternal immune responses.

In conclusion, a normal, healthy endometrial state, including the local immune environment, is crucial not only for fertility but also for placenta formation, since the initiation of placentation highly depends on interaction between trophoblasts and immune cells such as decidual natural killer cells and T cells. Future research is needed to increase our understanding of how the vagina and the uterus are colonized by microbes; how these microbiomes influence the modulation of the immune system and how this interplay influences implantation, placental development and pregnancy outcome.

This Research Topic aims to summarize recent developments in the field, focusing on:
(a) Current knowledge of normal female genital tract microbiome
(b) Immunity and maternal microbiome
(c) The interplay between immunity, maternal uterine, vaginal and gut microbiome and obstetric syndromes (recurrent pregnancy loss, placental-insufficiency, preterm delivery etc.)
(d) Novel therapeutic approaches towards restoring a normal female genital tract microbiome
(e) How maternal uterine, vaginal and gut microbiome may impact preterm infant microbiome composition and the future wellbeing of newborns



Journal Archive

Volume: 3 Issue: 1 Volume: 2 Issue: 1 Volume: 1 Issue: 1

Journal Recent Articles

Author: Alhassan Hussaini Mohammed
The Differentiation and Roles of inflammatory Cytokine in the initiation of Inflammatory Bowel Diseases (IBD)
Author: Dr. ALHASSAN Hussain
The Regulations of Gene Expressions by 1α,25(OH)2D3 in Patients with Inflammatory Bowel Diseases
Author: Dr. ALHASSAN Hussain
PROFILE OF INTERLEUKIN-1β IN CERVICAL CANCER PATIENTS ATTENDING ONCOLOGY UNIT, USMANU DANFODIYO UNIVERSITY TEACHING HOSPITAL, SOKOTO-NIGERIA.
Author: Tsvetelina Velikova
Increased percentages of Th17 cells showed an association with poorly controlled bronchial asthma in the childhood
Author: Fulvia Gloria-Bottini
IMMUNE RELATED DISEASES AND THEIR RELATIONSHIP WITH THE GENETIC VARIABILITY WITHIN THE ADENOSINE DEAMINASE GENE
Author: ANA LÚCIA MORENO AMOR
ENTEROPARASITES, RESPIRATORY ALLERGY AND OTHER SIGNS AND SYMPTOMS IN CHILDS AND YOUTH POPULATION OF RECÔNCAVO OF BAHIA – BRAZIL
Author: Bassey E. Bassey
OPTIMAL CONTROL MODEL FOR IMMUNE EFFECTORS RESPONSE AND MULTIPLE CHEMOTHERAPY TREATMENT (MCT) OF DUAL DELAYED HIV - PATHOGEN INFECTIONS
Author: Daniel Teshome Gebeyehu
A Review on Sheep pulmonary Adenocarcinoma
Author: Rodney P Jones
Outbreaks of a presumed infectious pathogen creating on/off switching in deaths
Author: Yihong Hu
Nucleic Acid Sequence-Based Amplification in Diagnosis of Disease Pathogens
Author: Ozlem Sancakli
Proctocolitis in a child treated with oral immunotherapy for cow’s milk allergy
Author: Humaa Bhatti
Participation in Multidisciplinary Team Clinic Results in Improved Outcomes in Inner City Asthmatic Children
Author: Ken-ichi Isobe
Murine model of obesity-induced type II diabetes by GADD34 (PPP1R15A) and other phosphatase 1 regulatory subunits deficiency.
Author: Merritt Fajt MD
Atypical DRESS Syndrome in a Post-Partum Patient
Author: Merritt Fajt MD
Non-ionic Contrast Allergy Manifesting as Stevens Johnson Syndrome and Erythema Multiforme

CONTACT US

Sift Desk Journals,
#591, 600 Madison Ave,
NY, 10022, USA
Call Us: +16469050407
info@siftdesk.org

JOURNALS LINKS

  • Food Science
  • Environmental Studies
  • Computational Chemistry
  • Chemical Engineering
  • Anesthesia & Surgery
  • Cellular & Molecular Physiology
  • Plant Science
  • Aquaculture & Fish Science
  • Nano Technology & Materials Science
  • Allergy & Immunology

QUICK CONTACT

Sift Desk Journals