Journal of Advances In Allergy & Immunologic Diseases
Call Us: +1 6469050407
  editor@siftdesk.org Sign In | Register
  • Home
  • About Us
  • Journals
  • Guidelines
    • Author Guidelines
    • Editor Guidelines
    • Reviewer Guidelines
  • Policies
    • Publication Ethics
    • Peer Review
    • Open Access
    • Terms & Conditions
Logo
  • Journal Home
  • Special Issue Topics
  • Article In Press
  • Current Issue
  • Archive
  • Submit Manuscript
  • Editorial Members
  • Indexing Archive
  • Processing Fee

© 2010 - 2020 Copyright Sift Desk Journals. All Rights Reserved

profile

Journal of Advances In Allergy & Immunologic Diseases

Journal of Advances In Allergy & Immunologic Diseases(JAAID)

ISSN: 2575-6184

Impact Factor: 0.431

Dendritic Cell-based Immunotherapy in Solid and Haematologic Tumors

Submit Manuscript on this topic
Indexed Articles

Description

Dendritic cells (DCs) play a critical role in orchestrating antitumor immune responses due to their capability of regulating innate and adaptive immunity. DCs can elicit tumor specific cytotoxic immunity through both the induction of antigen-specific CD4+ and CD8+ T lymphocytes and the stimulation of killing activity of innate immune cells, such as NK cells and NKT cells. Although a compelling body of preclinical studies strongly supports the potential application of DCs in the treatment of solid and hematologic tumors, DC-based immunotherapy remains rarely used in the clinical practice. Moreover, in the last decade, the clinical trials employing DC-based vaccines, often as monotherapy, showed unsatisfactory clinical benefits, hence discouraging the oncologists.

At present, the rapidly progressing advances in deciphering immunoescape mechanisms of cancer cells highlight the promising therapeutic relevance of combining classical anticancer treatments or target therapies with immunotherapeutic strategies and, in particular, with DC-based vaccines. The current challenge is the definition of the most effective and safe therapeutic combination. This may be accomplished by improving our knowledge on how conventional anticancer drugs and small molecule inhibitors could affect and modulate DC functions. Moreover, a deeper knowledge of molecular mechanisms, signaling pathways and epigenetic regulation of DC biology is needed to exploit the full potential of DC-based immunotherapies. An emerging area of clinical relevance is the combination of DC-based vaccines with immune checkpoint inhibition, whose rationale is supported by convincing preclinical data demonstrating therapeutic synergism and improved efficacy with a retained safety profile.

On this ground, this Research Topic aims to provide a comprehensive overview of the recent advances in developing optimized DC-based cancer vaccines and their experimental and clinical exploitation in combination with different therapies. To this end, we would encourage submission of Original Research articles, Reviews, Mini-Reviews and Opinion articles that cover, but are not limited to, the following topics:

· Modulation of DC functions by anticancer treatments
· Role of different signaling pathways in DC maturation and activation in cancer
· Metabolic control of DC function in cancer
· Epigenetic mechanisms underlying DC function regulation in cancer
· Role of DC in the induction of T cell response vs T cell tolerance in cancer
· Cross-talk between DC and other immune effectors in anticancer immunity
· Potential predictive markers of a successful response to DC-based therapeutic approaches
· Novel technology development to target and activate anticancer DC in vivo



Journal Archive

Volume: 3 Issue: 1 Volume: 2 Issue: 1 Volume: 1 Issue: 1

Journal Recent Articles

Author: Alhassan Hussaini Mohammed
The Differentiation and Roles of inflammatory Cytokine in the initiation of Inflammatory Bowel Diseases (IBD)
Author: Dr. ALHASSAN Hussain
The Regulations of Gene Expressions by 1α,25(OH)2D3 in Patients with Inflammatory Bowel Diseases
Author: Dr. ALHASSAN Hussain
PROFILE OF INTERLEUKIN-1β IN CERVICAL CANCER PATIENTS ATTENDING ONCOLOGY UNIT, USMANU DANFODIYO UNIVERSITY TEACHING HOSPITAL, SOKOTO-NIGERIA.
Author: Tsvetelina Velikova
Increased percentages of Th17 cells showed an association with poorly controlled bronchial asthma in the childhood
Author: Fulvia Gloria-Bottini
IMMUNE RELATED DISEASES AND THEIR RELATIONSHIP WITH THE GENETIC VARIABILITY WITHIN THE ADENOSINE DEAMINASE GENE
Author: ANA LÚCIA MORENO AMOR
ENTEROPARASITES, RESPIRATORY ALLERGY AND OTHER SIGNS AND SYMPTOMS IN CHILDS AND YOUTH POPULATION OF RECÔNCAVO OF BAHIA – BRAZIL
Author: Bassey E. Bassey
OPTIMAL CONTROL MODEL FOR IMMUNE EFFECTORS RESPONSE AND MULTIPLE CHEMOTHERAPY TREATMENT (MCT) OF DUAL DELAYED HIV - PATHOGEN INFECTIONS
Author: Daniel Teshome Gebeyehu
A Review on Sheep pulmonary Adenocarcinoma
Author: Rodney P Jones
Outbreaks of a presumed infectious pathogen creating on/off switching in deaths
Author: Yihong Hu
Nucleic Acid Sequence-Based Amplification in Diagnosis of Disease Pathogens
Author: Ozlem Sancakli
Proctocolitis in a child treated with oral immunotherapy for cow’s milk allergy
Author: Humaa Bhatti
Participation in Multidisciplinary Team Clinic Results in Improved Outcomes in Inner City Asthmatic Children
Author: Ken-ichi Isobe
Murine model of obesity-induced type II diabetes by GADD34 (PPP1R15A) and other phosphatase 1 regulatory subunits deficiency.
Author: Merritt Fajt MD
Atypical DRESS Syndrome in a Post-Partum Patient
Author: Merritt Fajt MD
Non-ionic Contrast Allergy Manifesting as Stevens Johnson Syndrome and Erythema Multiforme

CONTACT US

Sift Desk Journals,
#591, 600 Madison Ave,
NY, 10022, USA
Call Us: +16469050407
info@siftdesk.org

JOURNALS LINKS

  • Food Science
  • Environmental Studies
  • Computational Chemistry
  • Chemical Engineering
  • Anesthesia & Surgery
  • Cellular & Molecular Physiology
  • Plant Science
  • Aquaculture & Fish Science
  • Nano Technology & Materials Science
  • Allergy & Immunology

QUICK CONTACT

Sift Desk Journals