Derek Whelan; Brian D O'Donnell; Anthony JP Clover
Laura Kearney, Fibrin hydrogel as a novel delivery agent for local anesthetics: issues in demonstrating its efficacy at in vitro level(2017)SDRP Journal of Anesthesia & Surgery 2(2)
There is an identified need within the field of pain management to optimise the delivery of local anaesthetic agents as slow release formulations. Fibrin gel has shown huge potential for the local delivery of drugs including antibiotics, vasodilators, and chemotherapeutic agents however its potential for the delivery of local anaesthetic drugs has not, as yet, been fully investigated. Early randomized controlled trials have demonstrated efficacy, but to date, these have been relatively few and report the gross effect rather than specific kinetics. 1-3 The authors designed an in-vitro study aiming to evaluate sustained release of a local anesthetic agent from loaded fibrin gels over time.