[New glucose-lowering drugs for reducing cardiovascular risk in patients with type2 diabetes mellitus].


Unidad de Endocrinología y Nutrición, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, España. Electronic address: [Email]


Cardiovascular (CV) disease is the most common cause of mortality in patients with type2 diabetes (T2DM). In recent years, several glucose-lowering drugs from two therapeutic families, GLP-1 receptor agonists (GLP-1 RAs) and sodium-glucose co-transporter type 2 inhibitors (SGLT-2i), have shown a reduction in CV morbidity and mortality in patients with T2DM and high CV risk. SGLT-2i, unlike GLP-1 RAs, also reduce the risk of hospital admission due to heart failure. Both therapeutic groups reduce the progression of diabetic kidney disease (DKD). The cardioprotective mechanism of SGLT-2i appears to be predominantly haemodynamic and shows an early onset, while that of GLP-1 RAs is mostly anti-atherosclerotic with a slow and progressive onset. At present, several scientific societies recommend the preferential use of GLP-1 RAs and SGLT-2i, with demonstrated CV benefit in patients with T2DM and cardiovascular disease or DKD.


Agonistas del receptor de GLP-1,Cardiovascular disease,Diabetes mellitus tipo2,Enfermedad cardiovascular,GLP-1 receptor agonists,Inhibidores del co-transportador sodio-glucosa tipo2,Sodium-glucose co-transporter type2 inhibitors,Type2 diabetes mellitus,

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