A comparison of lithium-substituted phosphate and borate bioactive glasses for mineralised tissue repair.


Centre for Craniofacial and Regenerative Biology, King's College London, London SE1 9RT, UK. Electronic address: [Email]


Wnt/β-catenin signalling plays important roles in regeneration, particularly in hard tissues such as bone and teeth, and can be regulated by small molecule antagonists of glycogen synthase kinase 3 (GSK3); however, small molecules can be difficult to deliver clinically. Lithium (Li) is also a GSK3 antagonist and can be incorporated into bioactive glasses (BG), which can be used clinically in dental and bone repair applications and tuned to quickly release their constituent ions.


Bioactive glass,Lithium,Regeneration,Wnt/β-catenin signalling,