A facile approach for the synthesis of nido-carborane fused oxazoles via one pot deboronation/cyclization of 9-amide-o-carboranes.


State Key Laboratory of Environment-friendly Energy Materials & School of Material Science and Engineering, Southwest University of Science and Technology, 59 Qinglong Road, Mianyang, Sichuan, P. R. China. [Email]


A one pot deboronation/cyclization of 9-amide-o-carboranes for the synthesis of nido-7,8-carborane fused oxazole by cooperation of Pd(OAc)2, AgOAc and K2CO3 has been developed. A plausible mechanism involving an amide directed electrophilic palladation of the B-H bond and deboronation/cyclization process was proposed based on the successful isolation and structural characterization of the key deboronated intermediate.