The Greenland Ice Sheet (GIS) has been losing mass at an accelerating rate over the recent decades. Models suggest a possible temperature threshold between 0.8 and 3.2 °C, beyond which GIS decline becomes irreversible. The duration of warmth above a given threshold is also a critical determinant for GIS survival, underlining the role of ocean warming, as its inertia prolongs warmth and triggers longer-term feedbacks. The exact point at which these feedbacks are triggered remains equivocal. Late Pleistocene interglacials provide potential case examples for constraining the past response of the GIS to a range of climate states, including conditions warmer than present. However, little is known about the magnitude and duration of warming near Greenland during these periods. Using high-resolution multiproxy surface ocean climate records off southern Greenland, we show that the previous 4 interglacials over the last ∼450 ka all reached warmer than present climate conditions and exceeded the modeled temperature threshold for GIS collapse but by different magnitudes and durations. Complete deglaciation of the southern GIS in Marine Isotope Stage 11c (MIS 11c; 394.7 to 424.2 ka) occurred under climates only slightly warmer than present (∼0.5 ± 1.6 °C), placing the temperature threshold for major GIS retreat in the lower end of model estimates and within projections for this century.