A scalable solution for isolating human multipotent clinical-grade neural stem cells from ES precursors.


Gene Expression Laboratory, Howard Hughes Medical Institute and Salk Institute for Biological Studies, 10010 North Torrey Pines Rd, La Jolla, CA, 92037, USA. [Email]


A well-characterized method has not yet been established to reproducibly, efficiently, and safely isolate large numbers of clinical-grade multipotent human neural stem cells (hNSCs) from embryonic stem cells (hESCs). Consequently, the transplantation of neurogenic/gliogenic precursors into the CNS for the purpose of cell replacement or neuroprotection in humans with injury or disease has not achieved widespread testing and implementation.


Amyotrophic lateral sclerosis (ALS),Bioinformatic tools to study xenografts,Human embryonic stem cell (hESC),Neural stem cell (NSC),Spinal cord,Spinal traumatic injury,

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