School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, PR China; National Engineering Research Center for Nanotechnology, Shanghai 200241, PR China. Electronic address: [Email]
A versatile of mesoporous silica is designed and operated, including ion doping, surface modify and pore adsorption, based on aqueous well-dispersed. Thus, a multifunctional theranostic nanoplatform is obtained through endowing some functional materials. Detailedly, Gd ions is introduced to mesoporous silica (GM nanoparticles) via a co-assemble process, which is used as prime carrier with MRI. Furthermore, the surface graft of hyaluronic acid (HA) molecule makes contribution to lymph system-targeted delivery (GMH nanoparticles). Additionally, the introduction of functional molecules including Iopamidol (IGMH nanoparticles) and DOX (DGMH nanoparticles) could combine the diagnosis and therapy with CT and sustained drug release. We present evidence that the IGMH and DGMH nanoparticles are highly targeted to lymph system in vitro and in vivo, and highlight CT and MR imaging of IGMH nanoparticles in lymph system, and chemotherapy and MR imaging of DGMH nanoparticles in lymph cancer. Our results provide a new universal manufacture for mesoporous silica to obtain a multifunctional theranostic nanoplatform, has great potential for use in biological applications.