Abnormal resting-state cerebral-limbic functional connectivity in bipolar depression and unipolar depression.


Medical Psychological Center, Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China. [Email]


Distinctive patterns of functional connectivity (FC) abnormalities in neural circuitry has been reported in patients with bipolar depression (BD) and unipolar depression (UD). However, it is unclear that whether this distinct functional connectivity patterns are diagnosis specific between BD and UD. This study aimed to compare patterns of functional connectivity among BD, UD and healthy controls (HC) and determine the distinct functional connectivity patterns which can differentiate BD from UD.


Cerebral-limbic,Depression,Functional activity,Resting-state,