Adjuvant and antigenic properties of Mycobacterium avium subsp. paratuberculosis on experimental autoimmune encephalomyelitis.


Juntendo University, Department of Neurology, Tokyo, Japan; Juntendo University, Department of Treatment and Research in Multiple Sclerosis and Neuro-intractable disease, Tokyo, Japan. Electronic address: [Email]


Mycobacterium avium subsp. paratuberculosis (MAP), the causative agent of Johne's disease in ruminants, has been linked as a possible risk factor for human multiple sclerosis. In the current study we investigated the adjuvant effect of MAP on experimental autoimmune encephalomyelitis (EAE). Groups of C57BL/6 mice were actively immunized with myelin oligodendrocyte glycoprotein (MOG) 35-55 peptide emulsified in incomplete Freund's adjuvant modified containing heat-killed MAP (MIFA). MOG-MIFA immunized mice showed an early disease onset and more severe clinical scores in comparison with MOG-CFA immunized mice, demonstrating for the first time the adjuvant effect of MAP on EAE development.


Adjuvant,C57BL/6J mice,Experimental autoimmune encephalomyelitis,Mycobacterium avium subsp. paratuberculosis,

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