Aggregation induced emission-active two-photon absorption zwitterionic chromophore for bioimaging application.


Institute of Physics Science and Information Technology, College of Chemistry and Chemical Engineering, Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Anhui University, Hefei, 230601, PR China. Electronic address: [Email]


The fabrication of two-photon absorption material is a versatile approach to achieve high resolution bioimaging with low phototoxicity yet remain sophisticated. Herein, a zwitterionic chromophore, MF, with D-π-A configuration has been rational designed and synthesized. Remarkably, MF exhibited enhanced one- and two-photon fluorescent in the aggregation states. Additionally, the obtained MFNPs encapsulated by Pluronic F-127, could be employed as a two-photon fluorescent probe for bioimaging. The results reveal that MFNPs could target mitochondria by using two-photon confocal microscopy and stimulated emission depletion nanoscopy methods.


Aggregation induced emission,Bioimaging,Mitochondria,Two-photon,

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