Aggressive Pituitary Tumor with Crooke's Cells and Invasion of the Posterior Fossa.


Lyerly Neurosurgery, Baptist Neurological Institute, Jacksonville, Florida, USA. Electronic address: [Email]


BACKGROUND : Pituitary adenomas are mostly benign in character and are managed via transsphenoidal approach in the majority of the cases. Crooke's cell adenoma (CCA) is a particular variant accounting for less than 1% percent of the pituitary adenomas. They have a distinctive histopathologic pattern and behavior.
METHODS : We present a case of a 56-year-old man with recurrent pituitary adenoma and complicated neurosurgical history. Imaging followup showed a suprasellar mass with progressive growth into the posterior fossa. Surgical management via retrosigmoid craniectomy was performed, and histopathology elucidated Crooke's cells.
CONCLUSIONS : Crooke's cell adenoma is recognized by its local aggressiveness and high recurrence rates. They tend to be locally invasive, though, posterior fossa invasion has not been reported to date. We aim to contribute to the arsenal of differential diagnosis of similar pituitary tumor cases.


Crooke’s cells,Crooke’s cells Tumor,Pituitary adenoma,Posterior fossa invasion,Skull Base,Transsphenoidal’,

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