An AIE fluorescent probe with a naphthalimide derivative and its application for detection of hypochlorite and imaging inside living cells.


Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Key Laboratory of Guangxi Colleges and Universities for Food Safety and Pharmaceutical Analytical Chemistry, School of Chemistry and Chemical Engineering, Guangxi University for Nationalities, Nanning 530008, China. Electronic address: [Email]


Hypochlorite (ClO-) is a highly reactive oxygen species that plays an important role in resistance to attacks by microorganisms. Herein, we report the preparation of a fluorescence probe (NIB-M) through the integration of a naphthalimide moiety and ClO- to capture diaminomaleonitrile and employ it for the aggregation-induced emission-based (AIE-based) monitoring of ClO-. In the presence of ClO-, NIB-M undergoes sequential nucleophilic substitution and HCl elimination reactions that allow it to possess high selectivity, a fast response, and a low detection limit (0.032 μM). Due to the good AIE properties of the parent molecule, a ClO- test board was facilely prepared by loading NIB-M on a Whatman paper strip-based portable device. The test plate can conveniently and sensitively detect hypochlorite onsite. In addition, the NIB-M probe was used for the imaging of exogenous/endogenous ClO- inside living cells.


AIE,Fluorescent probe,Hypochlorite,Naphthalimide derivatives,

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