Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer.

Affiliation

Department of Biotechnology and Life Science, Faculty of Engineering, Tokyo University of Agriculture and Technology, 2-24-18, Naka-cho, Koganei-shi, Tokyo 184-8588, Japan. Electronic address: [Email]

Abstract

OSW-1 is a plant-derived natural product proposed to selectively kill cancer cells by binding to members of the oxysterol binding protein family, thereby disrupting lipid/sterol homeostasis. However, how these protein-ligand interactions mediate cell death signaling has remained elusive. Here, we discovered that OSW-1 selectively activates the Golgi stress response leading to apoptosis, providing a mechanistic basis for the anticancer activity of OSW-1.

Keywords

Anticancer natural product,Golgi stress response,OSBP,OSW-1,Saponin,

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