Association between High Levels of Circulating Chemerin and Colorectal Adenoma in Men.

Affiliation

Faculty of Medicine, Department of Gastroenterology, Yamagata University, Yamagata, Japan, [Email]

Abstract

BACKGROUND : Obesity and metabolic syndrome are considered the risk factors of colorectal adenoma (CRA) and colorectal cancer (CRC). Chemerin is a novel adipocytokine associated with the development of gastric cancer, esophageal cancer, hepatocellular carcinoma, and CRC. However, the relationship between chemerin levels and CRA remains unclear.
OBJECTIVE : This study is aimed at investigating the -association between serum chemerin levels and the development of CRA.
METHODS : We conducted a total colonoscopy-based cross-sectional case-control study of 80 male patients with CRA and 80 male age-matched control individuals without CRA, according to their endoscopic findings. Serum chemerin concentrations were measured using a sandwich enzyme-linked immunosorbent assay kit, and the OR of CRA was calculated via logistic regression analysis.
RESULTS : The mean serum chemerin level of the CRA group was significantly higher than that of the control group (7.9 ± 0.41 vs. 5.16 ± 0.34 ng/mL, p < 0.001). Serum chemerin level was positively correlated to the development of CRA (r = 0.34). Multivariate logistic regression analysis revealed that a high chemerin level was independently associated with the development of CRA (OR 2.82, 95% CI 1.39-5.72).
CONCLUSIONS : Our findings indicated that increased serum chemerin levels are positively associated with the presence of CRA in men. Chemerin may play an important role in the development of CRA.

Keywords

Adipocytokine,Colorectal cancer,Insulin resistance,Metabolic syndrome,Obesity,

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