Association between subclinical hypothyroidism and depression: an updated systematic review and meta-analysis.


Faculty of Medicine and Health Sciences, University of Malaysia Sarawak(UNIMAS), Jalan Dato Muhammad Musa, 94300, Kota Samarahan, Sarawak, Malaysia. [Email]


Although depression is associated with changes in the hypothalamic-pituitary-thyroid axis, its relationship with subclinical hypothyroidism (SCH) is controversial. To date, there is a lack of data on the improvement of depressive symptoms with levothyroxine therapy among individuals with coexistent SCH.


Depression,Levothyroxine,Subclinical hypothyroidism,Thyroid stimulating hormone,

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