Boronate-crosslinked polysaccharide conjugates for pH-responsive and targeted drug delivery.


College of Science, Inner Mongolia Agricultural University, Hohhot 010018, P. R. China and Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China. [Email]


A pH-responsive and targeted polysaccharide conjugate was fabricated from the boronate linkage of N-(2-aminoethyl)-gluconamide-grafted hyaluronic acid with anticancer drug bortezomib, which could exhibit targeted drug release behaviors at acidic pH and possess lower cytotoxicity and a higher inhibition effect toward cancer cells.