Cardiac Valve Bioreactor for Physiological Conditioning and Hydrodynamic Performance Assessment.


Department of Cardiovascular Medicine, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA. [Email]


Tissue engineered heart valves (TEHV) are being investigated to address the limitations of currently available valve prostheses. In order to advance a wide variety of TEHV approaches, the goal of this study was to develop a cardiac valve bioreactor system capable of conditioning living valves with a range of hydrodynamic conditions as well as capable of assessing hydrodynamic performance to ISO 5840 standards.


Biochemical stimulation,Biomechanical stimulation,ISO 5840,Three-dimensional tissue culture,Tissue engineered heart valve,