Childhood trauma and insulin resistance in patients suffering from depressive disorders.


Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, USA. Electronic address: [Email]


Insulin resistance (IR) is a metabolic dysfunction often co-morbid with major depressive disorder (MDD). The paths to development of MDD remain largely unspecified, highlighting a need for identification of risk factors. Here, we tested whether specific subscales of childhood trauma as well as family history of type-2 diabetes (Fam-Hx-Dm2) are risk factors for development of metabolic dysfunction and severity of depressive symptoms.


Childhood stress,Emotional abuse,Family history of type-2 diabetes,Insulin resistance,Insulin secretion,Risk factors,