OBJECTIVE : The objective of this clinical study was to compare and assess the clinical performance of tooth-supported and implant-supported zirconia single crowns with sintered veneering caps. METHODS : In this prospective study, 118 patients with a total of 220 single crowns placed on 106 teeth (69 vital teeth, 37 endodontically treated teeth) and 114 implants in molar and premolar regions were examined during a mean observation period of 42 months. The restorations were evaluated for technical failures such as veneering porcelain fractures (chipping), surface quality, marginal fit, and the interface quality of the coping and sintered veneering. The soft tissue status was assessed using the modified Silness and Löe's plaque and gingival index (mPI) and the modified Muhlemann sulcus bleeding index (mSBI). Tooth-supported crowns were checked for secondary caries and hypersensitivity during the follow-up period. Recalls were performed every 6 months. RESULTS : The 3-year Kaplan-Meier success probability was 98.2% and 100% for implant- and tooth-supported crowns, respectively. A significant difference could be detected between the implant-supported and tooth-supported zirconia single crowns, in terms of their chipping rate (p = 0.039). Veneering material fractures were recorded on two implant-supported restorations (1.8%). No veneering fractures occurred on tooth-supported single crowns. The plaque and gingival index and sulcus bleeding index showed stable and healthy soft peri-implant and periodontal tissues. Neither loss of vitality nor secondary caries occurred on tooth-supported crowns. CONCLUSIONS : Zirconia-based single crowns with a sintered veneering cap showed promising clinical results on both tooth and implant abutments; however, the dental implants were more prone to complications. In terms of clinical significance, high-strength ceramic with a sintered veneering cap can be recommended for prosthetic treatment of both tooth- and implant-supported single crowns in molar regions. CONCLUSIONS : This study provides valuable information for further application of all-ceramic restorations.