Clinically relevant mutations in core metabolic genes confer antibiotic resistance.

Affiliation

Lopatkin AJ(1)(2)(3)(4)(5)(6), Bening SC(1)(2), Manson AL(2), Stokes JM(1)(2)(3), Kohanski MA(7), Badran AH(2), Earl AM(2), Cheney NJ(8)(9), Yang JH(8)(9), Collins JJ(10)(2)(3)(11)(12).
Author information:
(1)Institute for Medical Engineering and Science and Department of Biological Engineering, Massachusetts Institute of Technology
(MIT), Cambridge, MA, USA.
(2)Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
(3)Wyss Institute for Biologically Inspired Engineering; Harvard University, Boston, MA, USA.
(4)Department of Biology, Barnard College, New York, NY, USA.
(5)Data Science Institute, Columbia University, New York, NY, USA.
(6)Ecology, Evolution, and Environmental Biology, Columbia University, New York, NY, USA.
(7)Department of Otorhinolaryngology-Head and Neck Surgery, Division of Rhinology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
(8)Ruy V. Lourenço Center for Emerging and Re-Emerging Pathogens, Rutgers New Jersey Medical School, Newark, NJ, USA.
(9)Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ, USA.
(10)Institute for Medical Engineering and Science and Department of Biological Engineering, Massachusetts Institute of Technology
(MIT), Cambridge, MA, USA. [Email]
(11)Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA, USA.
(12)Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA, USA.

Abstract

Comment in Science. 2021 Feb 19;371(6531):783-784. Nat Rev Microbiol. 2021 May;19(5):283.