The formation of structurally stable composites of cubic zirconia (c-ZrO2) with selective transition metal oxides (α-Fe2O3, Mn3O4, NiO, Co3O4) is investigated. The results affirm the prospect to retain unique c-ZrO2 and transition metal oxide (TMO) structures in the composite form until 1400 °C. It is also shown that 30 mol% Y2O3 possess the ability to retain stable c-ZrO2 despite the existence of assorted TMO content in the composites. The elemental states of Fe3+, Mn2+/4+, Ni2+ and Co2+/3+ are confirmed from the corresponding α-Fe2O3, Mn3O4, NiO, and Co3O4. The magnetic properties are highly influenced by the quantity of TMO component while the c-ZrO2 plays a decisive role in the resultant mechanical properties. The wide range of properties delivered by the composites extends the possibility to probe for osteosarcoma treatment that demands optimal mechanical and magnetic features.