Continuous feeding of a combined high-fat and high-sucrose diet, rather than an individual high-fat or high-sucrose diet, rapidly enhances the glucagon-like peptide-1 secretory response to meal ingestion in diet-induced obese rats.

Affiliation

Graduate School of Agriculture, Hokkaido University, Sapporo, Japan; Research Faculty of Agriculture, Hokkaido University, Sapporo, Japan. Electronic address: [Email]

Abstract

Glucagon-like peptide-1 (GLP-1) is secreted by enteroendocrine L-cells in response to nutrient ingestion. To date, GLP-1 secretion in diet-induced obesity is not well characterized. We aimed to examine GLP-1 secretion in response to meal ingestion during the progression of diet-induced obesity and determinewhether a combined high-fat and high-sucrose (HFS) diet, an individual high-fat (HiFat), or a high-sucrose (HiSuc) diet affect adaptive changes in the postprandial GLP-1 response.

Keywords

Glucagon-like peptide-1,L-cell,Luminal nutrients,Meal tolerance test,Obesity,

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