Cupuaçu extract reduces nitrosative stress and modulates inflammatory mediators in the kidneys of experimental diabetes.


Nephrology Division, Federal University of Sao Paulo, Sao Paulo, Brazil; Laboratory of Nitric Oxide and Oxidative Stress, Federal University of Sao Paulo, Sao Paulo, Brazil. Electronic address: [Email]


We have previously reported an increased nitrosative stress in the kidneys of diabetic animals, which was reduced by an antioxidant probiotic. The present study evaluated whether the extract of cupuaçu (EC), an antioxidant compound rich in polyphenols and theograndins, when administered at a dose that can be reasonably obtained through daily consumption, could delay the onset of diabetic complications in the kidney.


Diabetic kidney,Immortalized mesangial cells,Inflammation,Theobroma,

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