DNA damage response of clinical carbon ion versus photon radiation in human glioblastoma cells.

Affiliation

CCU Molecular and Radiation Oncology, German Cancer Research Center and Department of Radiation Oncology, Heidelberg University Hospital, Germany. Electronic address: [Email]

Abstract

Carbon ion radiotherapy is a promising therapeutic option for glioblastoma patients due to its high physical dose conformity and greater biological effectiveness than photons. However, the biological effects of carbon ion radiation are still incompletely understood. Here, we systematically compared the biological effects of clinically used carbon ion radiation to photon radiation with emphasis on DNA repair.

Keywords

Carbon ion radiotherapy,DNA double-strand breaks,DNA repair,Glioblastoma,Homologous recombination,