Developmental exposure to a very low dose of bisphenol A induces persistent islet insulin hypersecretion in Fischer 344 rat offspring.

Affiliation

Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden. Electronic address: [Email]

Abstract

In children with obesity, accentuated insulin secretion has been coupled with development of type 2 diabetes mellitus (T2DM). Bisphenol A (BPA) is a chemical with endocrine- and metabolism-disrupting properties which can be measured in a majority of the population. Exposure to BPA has been associated with the development of metabolic diseases including T2DM.

Keywords

Bisphenol A,Endocrine disruptor,Fischer 344 rats,Insulin hypersecretion,Islets of Langerhans,

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