Drug-induced systemic lupus: revisiting the ever-changing spectrum of the disease using the WHO pharmacovigilance database.


Service de rhumatologie, Hôpitaux Universitaires de Strasbourg, Laboratoire d'Immuno Rhumatologie Moléculaire, INSERM UMR_S1109, Strasbourg, France [Email]


Drug-induced lupus (DIL) is an idiosyncratic side effect of treatments in which symptoms overlap with those of systemic lupus erythematosus (SLE). The spectrum of DIL constantly evolves with that of the pharmacopoeia. Here, we used VigiBase, the WHO global individual case safety reports (ICSRs) database, to identify the main drugs associated with DIL.


adverse-drug reaction,drug-induced lupus,pharmacovigilance,systemic lupus erythematosus,

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