Duloxetine plasma level and antidepressant response.

Affiliation

Department of Biomedical and Neuromotor Science, University of Bologna, Bologna, Italy. Electronic address: [Email]

Abstract

Major Depressive Disorder (MDD) is associated with a high rate of inadequate treatment response, which is mainly due to the large inter-individual genetic variability in pharmacokinetic and pharmacodynamic targets of antidepressant drugs. Little is still known about the exact association between plasma level of first-line antidepressants and clinical response. This is particularly true for duloxetine, a dual serotonin and norepinephrine reuptake inhibitor recommended as first-line treatment for MDD. The aim of this study was to investigate the association between serum concentration of duloxetine (SCD) and antidepressant response (AR).

Keywords

Antidepressant response,Duloxetine,Major depression,Serum concentration,Therapeutic drug monitoring,

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