Duloxetine plasma level and antidepressant response.


Department of Biomedical and Neuromotor Science, University of Bologna, Bologna, Italy. Electronic address: [Email]


Major Depressive Disorder (MDD) is associated with a high rate of inadequate treatment response, which is mainly due to the large inter-individual genetic variability in pharmacokinetic and pharmacodynamic targets of antidepressant drugs. Little is still known about the exact association between plasma level of first-line antidepressants and clinical response. This is particularly true for duloxetine, a dual serotonin and norepinephrine reuptake inhibitor recommended as first-line treatment for MDD. The aim of this study was to investigate the association between serum concentration of duloxetine (SCD) and antidepressant response (AR).


Antidepressant response,Duloxetine,Major depression,Serum concentration,Therapeutic drug monitoring,

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