Ebola Virus Replication Stands Out.

Affiliation

Department of Pathology and Immunology, Washington University School of Medicine in St Louis, St Louis, MO 63110, USA; Department of Medicine, Washington University School of Medicine in St Louis, St Louis, MO 63110, USA. Electronic address: [Email]

Abstract

A recent study by Deflubé et al. (Proc. Natl. Acad. Sci. U. S. A. 2019;116:8535-8543) reported that Ebola virus genomes have variable 3' terminal nucleotides. This finding is a departure from other nonsegmented, negative-strand RNA viruses (NNSVs) that have been studied to date and has broad implications for filoviral replication and innate immune evasion.

Keywords

Ebola virus,innate immune evasion,replication initiation,

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