Effects of Adjuvant Chemotherapy on Cognitive Function of Patients With Early-stage Colorectal Cancer.


Discipline of Radiology and Oncology, Instituto do Câncer do Estado de São Paulo, São Paulo, Brazil; Department of Oncology, AC Camargo Cancer Center, São Paulo, Brazil. Electronic address: [Email]


Chemotherapy-related cognitive impairment can occur in cancer survivors after treatment, especially those patients who have undergone chemotherapy for breast cancer. The frequency and to what extent such toxicity develops in colorectal cancer (CRC) survivors is unknown. The present prospective study evaluated the effects of adjuvant chemotherapy on the cognitive performance of patients with localized CRC compared with a control group who had not undergone chemotherapy.


Apolipoprotein,CRC,Cognition,Diffusion tensor imaging,Magnetic resonance imaging,