Eight new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa.


Pharmaceutical Institute, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address: [Email]


Eight new annonaceous acetogenins, squamotin A-D (1-4), annosquatin IV-V (5 and 6), muricin O (7) and squamosten B (8), together with four known ones (9-12) were isolated from the seeds of Annona squamosa. Their structures were elucidated by chemical methods and spectral data. The inhibitory activities of compound 1-9 against three multidrug resistance cell lines were evaluated. All tested compounds showed strong cytotoxicity.


Annona squamosa,Annonaceous acetogenins,Cytotoxicity,Multidrug resistance,

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