Epigenetic modulation enhances immunotherapy for hepatocellular carcinoma.

Affiliation

Division of Surgical Oncology, Hiram C. Polk Jr. M.D. Department of Surgery, University of Louisville School of Medicine, Louisville, KY 40202, USA; Department of Pharmacology & Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA. Electronic address: [Email]

Abstract

Anti-PDL-1 immunotherapy for Hepatocellular Carcinoma (HCC) demonstrated a mixed response. Polycomb Repressor Complex 2(PRC2) contributes to the initiation and progression of HCC by suppressing tumor antigens and inhibiting an immune response. Two components of epigenetic modulation are Enhancer of Zeste Homolog 2 (EZH2, the catalytic component of PRC2) and DNA Methyltransferase 1 (DNMT1). We aim to investigate the potential role of epigenetic therapy targeting EZH2 and DNMT1 as a novel strategy to modulate immunotherapy response in HCC.

Keywords

Checkpoint inhibitors,Epigenetic modulation,HCC,Immunotherapy,

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