Evaluation of imidazole and its derivative against Newcastle disease virus infection in chicken: A drug repurposing approach.

Affiliation

Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, 781039, Assam, India. Electronic address: [Email]

Abstract

Despite recent progress in vaccination options, Newcastle disease virus (NDV) stands a severe global epidemic and economic burden. It is difficult to control NDV with vaccination alone due to its evolving genetic variability; therefore, an effective therapeutic must target to resist its replication and further evolution. Drug repurposing is a practical and economical method to develop therapeutics against pathogenic organisms. Applying the knowledge of the broadly used antimicrobial activity of imidazole and its derivatives, we performed repurposing-based design of therapeutics to induce protection against NDV. We checked the ability of the compound at sub-lethal doses to reduce NDV replication in vitro, in ovo and in vivo. Chickens treated with the repurposed drug produced antiviral type I interferon and showed no shedding of the virus. Successful designing of novel NDV drug, in this study empirically demonstrates the principle that repurposing can be used for developing antiviral therapeutics.

Keywords

Imidazole,Newcastle disease virus,Pathogenicity,Replication,Repurposing,