Exploring the relationship between Endothelin-1 and peripheral inflammation in multiple sclerosis.


Neuropsychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA. Electronic address: [Email]


Identifying pathways linking neuroinflammation and neurodegeneration is essential to help prevent disability progression in people with multiple sclerosis (MS). Endothelin-1 (ET-1) is a potent vasoconstrictor thought to contribute to cerebral hypoperfusion and tissue damage in MS. Its link with the neuroinflammatory process remains poorly investigated.


Cytokines,Endothelin-1,Inflammation,Multiple sclerosis,Th1/Th2 response,