Fabrication and in vitro dissolution evaluation of low-crystalline β-TCP blocks through aqueous solution mediated phase conversion.


Department of Biomaterials, Faculty of Dental Science, Kyushu University, 3-1-1, Maidashi, Higashi, Fukuoka 812-8532, Japan. Electronic address: [Email]


Magnesium substituted low crystalline β‑tricalcium phosphates (LC-β-TCP) is an attractive biomaterials owing to its high initial osteoconductivity and bone regeneration. The present investigation is focused on fabrication of low crystalline β-TCP (LC-β-TCP) and evaluating in vitro dissolution toward to the crystallinity of the LC-β-TCP. It is suggested that the crystallinity of biocompatible ceramics greatly affect into their biocompatibility. The novelty of the work is the preparation of the LC-β-TCP without any calcium carbonate/phosphate complex, which is commonly in use. LC-β-TCP was fabricated from MgHPO4·3H2O (MgP) and CaCl2 aqueous solution at 200 °C hydrothermal condition. In vitro dissolution evaluations simulated osteoclast condition indicated the release of Mg2+ and Ca2+. It is suggested that LC -β-TCP fabricated by the given method could be useful material for bone regeneration because it has both low crystallinity and suitable Ca2+ and Mg2+ releasing and most importantly it does not contain any extended protocol.


Dissolution,Low crystalline,Mg-β-TCP,β-TCP,

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