Fostering mesenchymal stem cell therapy to halt cytokine storm in COVID-19.

Affiliation

Jeyaraman M(1), John A(2), Koshy S(2), Ranjan R(3), Anudeep TC(4), Jain R(5), Swati K(6), Jha NK(7), Sharma A(8), Kesari KK(9), Prakash A(6), Nand P(7), Jha SK(10), Reddy PH(11).
Author information:
(1)Department of Orthopaedics, School of Medical Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India; Department of Biotechnology, School of Engineering & Technology, Sharda University, Greater Noida, Uttar Pradesh, India.
(2)Internal Medicine, Texas Tech University Health Sciences Center, 3601 4th Street/MS/9410/4B 207, Lubbock, TX 79430, United States of America.
(3)Department of Orthopaedics, School of Medical Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India.
(4)Department of Plastic Surgery, Topiwala National Medical College and BYL Nair Ch. Hospital, Mumbai, Maharashtra, India.
(5)School of Medical Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India.
(6)Department of Biotechnology, School of Life Science, Mahatma Gandhi Central University, Motihari, Bihar, India.
(7)Department of Biotechnology, School of Engineering & Technology, Sharda University, Greater Noida, Uttar Pradesh, India.
(8)Department of Life Science, School of Basic Science and Research, Sharda University, Greater Noida, Uttar Pradesh, India.
(9)Department of Applied Physics, School of Science, Aalto University, Espoo, Finland.
(10)Department of Biotechnology, School of Engineering & Technology, Sharda University, Greater Noida, Uttar Pradesh, India. Electronic address: [Email]
(11)Internal Medicine, Neuroscience/Pharmacology, Neurology, Public Health Departments and School of Health Professions, Texas Tech University Health Sciences Center, 3601 4th Street/MS/9410/4B 207, Lubbock, TX 79430, United States of America. Electronic address: [Email]

Abstract

The coronavirus disease 2019 (COVID-19) has been threatening the globe since the end of November 2019. The disease revealed cracks in the health care system as health care providers across the world were left without guidelines on definitive usage of pharmaceutical agents or vaccines. The World Health Organization (WHO) declared COVID-19 as a pandemic on the 11th of March 2020. Individuals with underlying systemic disorders have reported complications, such as cytokine storms, when infected with the virus. As the number of positive cases and the death toll across the globe continue to rise, various researchers have turned to cell based therapy using stem cells to combat COVID-19. The field of stem cells and regenerative medicine has provided a paradigm shift in treating a disease with minimally invasive techniques that provides maximal clinical and functional outcome for patients. With the available evidence of immunomodulatory and immune-privilege actions, mesenchymal stem cells (MSCs) can repair, regenerate and remodulate the native homeostasis of pulmonary parenchyma with improved pulmonary compliance. This article revolves around the usage of novel MSCs therapy for combating COVID-19.