Functional peroxisomes are required for β-cell integrity in mice.

Affiliation

KU Leuven - University of Leuven, Department of Pharmaceutical and Pharmacological Sciences, Laboratory of Cell Metabolism, B-3000, Leuven, Belgium. Electronic address: [Email]

Abstract

Peroxisomes play a crucial role in lipid and reactive oxygen species metabolism, but their importance for pancreatic β-cell functioning is presently unknown. To examine the contribution of peroxisomal metabolism to β-cell homeostasis in mice, we inactivated PEX5, the import receptor for peroxisomal matrix proteins, in an inducible and β-cell restricted manner (Rip-Pex5-/- mice).

Keywords

Apoptosis,Diabetes,High-fat diet,Islet,Peroxisome,β-cell,

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