Genome-resolved metagenomics of eukaryotic populations during early colonization of premature infants and in hospital rooms.

Affiliation

Department of Earth and Planetary Science, University of California, Berkeley, CA, USA. [Email]

Abstract

Fungal infections are a significant cause of mortality and morbidity in hospitalized preterm infants, yet little is known about eukaryotic colonization of infants and of the neonatal intensive care unit as a possible source of colonizing strains. This is partly because microbiome studies often utilize bacterial 16S rRNA marker gene sequencing, a technique that is blind to eukaryotic organisms. Knowledge gaps exist regarding the phylogeny and microdiversity of eukaryotes that colonize hospitalized infants, as well as potential reservoirs of eukaryotes in the hospital room built environment.

Keywords

Eukaryotes,Genome-resolved metagenomics,Hospital microbiome,Metagenomics,Neonatal intensive care unit,Premature infants,

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